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Abstract #2625

In vivo characterisation of tumour microstructure with VERDICT MRI

Eleftheria Panagiotaki 1 , Simon Walker-Samuel 2 , Bernard Siow 1,2 , Peter S Johnson 3 , Vineeth Rajkumar 3 , R.Barbara Pedley 3 , Mark F Lythgoe 2 , and Daniel C Alexander 1

1 Centre for Medical Image Computing, University College London, London, London, United Kingdom, 2 Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 3 UCL Cancer Institute, University College London, London, United Kingdom

This work presents a novel technique that quantifies and maps histological features of tumours, in vivo. The technique, named VERDICT (Vascular, Extracellular and Restricted DIffusion for Cytometry in Tumors), couples DW-MRI with a mathematical model of tumour tissue to access features such as cell size, vascular volume fraction, intra- and extracellular volume fractions, and pseudo-diffusivity associated with blood flow. We demonstrate the technique in two tumour xenograft models of colorectal cancer with contrasting cellular and vascular phenotypes. Experiments identified known differences in the microstructure of the tumours and a significant decrease in cell volume following administration of gemcitabine, possibly reflecting apoptotic volume decrease.

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