Abstract #2625
In vivo characterisation of tumour microstructure with VERDICT MRI
Eleftheria Panagiotaki 1 , Simon Walker-Samuel 2 , Bernard Siow 1,2 , Peter S Johnson 3 , Vineeth Rajkumar 3 , R.Barbara Pedley 3 , Mark F Lythgoe 2 , and Daniel C Alexander 1
1
Centre for Medical Image Computing,
University College London, London, London, United
Kingdom,
2
Centre
for Advanced Biomedical Imaging, University College
London, London, United Kingdom,
3
UCL
Cancer Institute, University College London, London,
United Kingdom
This work presents a novel technique that quantifies and
maps histological features of tumours, in vivo. The
technique, named VERDICT (Vascular, Extracellular and
Restricted DIffusion for Cytometry in Tumors), couples
DW-MRI with a mathematical model of tumour tissue to
access features such as cell size, vascular volume
fraction, intra- and extracellular volume fractions, and
pseudo-diffusivity associated with blood flow. We
demonstrate the technique in two tumour xenograft models
of colorectal cancer with contrasting cellular and
vascular phenotypes. Experiments identified known
differences in the microstructure of the tumours and a
significant decrease in cell volume following
administration of gemcitabine, possibly reflecting
apoptotic volume decrease.
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