Comparing diffusion-weighted MRI signals from ordered and disordered microstructures
Damien J McHugh 1,2 , Penny L Hubbard 1,2 , Josephine H Naish 1,2 , and Geoffrey JM Parker 1,2
Centre for Imaging Sciences, University of
Manchester, Manchester, United Kingdom,
Imaging Institute, University of Manchester, Manchester,
In this work we compare the diffusion-weighted MRI
signals obtained from diffusion experiments in ordered
and disordered microstructural environments. We used a
simple tissue model of impermeable spherical cells and
performed separate Monte Carlo diffusion simulations for
ordered and disordered cell packing geometries.
Synthetic signals were generated for pulse sequence
parameters available on clinical scanners. Differences
between the signals from ordered and disordered
microstructures were small when extra-cellular diffusion
alone was considered, and these differences were even
smaller when considering combined intra- and
extra-cellular diffusion. This suggests that the
diffusion signal is insensitive to the packing
geometrys order/disorder for the sequence parameters
and tissue properties covered here.
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