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Abstract #2631

A novel biophysical model that characterizes the distribution of anisotropic micro-structural environments with DWI (DIAMOND)

Benoit Scherrer 1 , Maxime Taquet 1 , Mustafa Sahin 2 , Sanjay P. Prabhu 1 , and Simon K. Warfield 1

1 Radiology, Harvard Medical School, Boston Children's Hospital, Boston, MA, United States, 2 Neurology, Harvard Medical School, Boston Children's Hospital, Boston, MA, United States

We propose a novel biophysical model of the diffusion that characterizes the distribution of three-dimensional (3D) microstructural environments in each voxel. This enables characterization of each fascicle in each voxel and of isotropic diffusion and may lead to novel biomarkers and novel investigations of the white-matter microstructure.

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