Abstract #2635
Evidence for the Detection of Microscopic Diffusion Anisotropy in Human Brain Gray Matter in Vivo
Marco Lawrenz 1,2 and Juergen Finsterbusch 1,2
1
Department of Systems Neuroscience,
University Medical Center Hamburg-Eppendorf, Hamburg,
Hamburg, Germany,
2
University
Medical Centers Hamburg-Kiel-Luebeck, Neuroimage Nord,
Hamburg-Kiel-Luebeck, Hamburg-Kiel-Luebeck, Germany
Double-wave-vector diffusion-weighting (DWV) experiments
involving two successively applied diffusion weightings
are able to detect diffusion anisotropy on a microscopic
scale, even if the diffusion macroscopically appears
isotropic. This has been demonstrated recently in a
human brain white matter region that yields a fractional
anisotropy of 0. In this study, human gray matter is
targeted in vivo using a DWV sequence with inversion
recovery to suppress WM signals and avoid partial
volumen effects. While no signal modulation is observed
in a fluid phantom, the modulation curve characteristic
for diffusion anisotropy is observed although the
modulation amplitude is reduced compared to WM.
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