Exchange and T2-relaxation effects in double pulsed field gradient experiments

Double Pulsed Field Gradient sequences have recently been used to detect novel tissue contrasts such as the Apparent Exchange Rate and Compartment Eccentricity. We compare the effects of compartmental specific T2-relaxation in both single and double pulsed field gradient sequences. We measure a decrease in the Apparent Diffusion Coefficient as either the mixing time or the echo time is increased indicating filtering of compartment specific signal components with fast diffusivities. Our results indicate that both single and double pulsed field gradient sequences should adopt for the same TE in all experiments to maintain the relative T2-relaxation weighting of the individual compartments.

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