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Abstract #2644

Reliability and sensitivity of intravoxel incoherent motion (IVIM) MRI in measuring cerebral perfusion

Wen-Chau Wu 1,2 , Kuan-Lin Chen 3 , and Shu-Hua Lien 3

1 Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan, 2 Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan, 3 Medcial Imaging, National Taiwan University Hospital, Taipei, Taiwan

Intravoxel incoherent motion (IVIM) MRI is a technique proposed for concurrent measurement of water diffusion coefficient D and perfusion-related pseudo-diffusion coefficient D*. In this study, we investigated the sensitivity of IVIM MRI in the brain by comparing with arterial spin-labeling (ASL) MRI. Monte Carlo simulation was performed to assess the reliability of the perfusion indexes derived from nonlinear fitting. Results show that IVIM perfusion indexes are less reliable when D*/D < 10 and vascular volume fraction f < 0.05. Overall, f is more robust an index than D*. ASL-derived blood flow values were found mildly correlated with fD* and f.

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