Abstract #2644
Reliability and sensitivity of intravoxel incoherent motion (IVIM) MRI in measuring cerebral perfusion
Wen-Chau Wu 1,2 , Kuan-Lin Chen 3 , and Shu-Hua Lien 3
1
Graduate Institute of Oncology, National
Taiwan University, Taipei, Taiwan,
2
Graduate
Institute of Clinical Medicine, National Taiwan
University, Taipei, Taiwan,
3
Medcial
Imaging, National Taiwan University Hospital, Taipei,
Taiwan
Intravoxel incoherent motion (IVIM) MRI is a technique
proposed for concurrent measurement of water diffusion
coefficient D and perfusion-related pseudo-diffusion
coefficient D*. In this study, we investigated the
sensitivity of IVIM MRI in the brain by comparing with
arterial spin-labeling (ASL) MRI. Monte Carlo simulation
was performed to assess the reliability of the perfusion
indexes derived from nonlinear fitting. Results show
that IVIM perfusion indexes are less reliable when D*/D
< 10 and vascular volume fraction f < 0.05. Overall, f
is more robust an index than D*. ASL-derived blood flow
values were found mildly correlated with fD* and f.
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