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Abstract #2650

Predicting the Quantitative Accuracy of In-Vivo ADC using an Ice-Water Phantom

David M. Morris 1 , Hossein Ragheb 1 , Neil Thacker 1 , Naomi H.M. Douglas 2 , and Alan Jackson 3

1 Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom, 2 Institute of Cancer Research, Sutton, United Kingdom, 3 Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom

Apparent diffusion Coefficient (ADC) is a biomarker shown to have efficacy in monitoring the response of tumors to interventions. To be used successfully in multi-center trials a quality assurance protocol must be developed using an ice water phantom. The results of a multi-vendor, multi-site trial using standardized protocols are presented where different measurements of the accuracy of the systems using the phantom are compared. Then the relationship of these with the variability observed within the normal liver of volunteers at each site. While the protocols can differentiate between scanners there is no predictive power for performance in-vivo .

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