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Abstract #2649

Do DTI reproducibility studies agree? A meta-analysis.

Pim Pullens 1 , Wim van Hecke 2 , and Paul M Parizel 1

1 Radiology, Antwerp University Hospital, Edegem, Antwerp, Belgium, 2 Icometrix, Leuven, Belgium

There is more and more interest in testing reproducibility of DTI measures, which could lead to use of DTI measures as clinical biomarkers. Coefficient of variation (std/mean) is often used to assess reproducibility. However, it is not trivial to compare CVs from different studies, each with a different number of subjects. In this meta-analysis across DTI reproducibility studies, we test if CVs are equal among published FA reproducibility studies with an appropriate statistical test. Results show that although confidence intervals of FA show deviations because of analysis or scanner type, CVs are comparable.

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