Abstract #2670
Mapping hippocampal connectivity of the live mouse brain with localized high resolution HARDI
Dan Wu 1 , Jiadi Xu 2 , Susumu Mori 2,3 , and Jiangyang Zhang 3
1
Biomedical Engineering, Johns Hopkins
University School of Medicine, Baltimore, Maryland,
United States,
2
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
States,
3
Radiology,
Johns Hopkins University School of Medicine, Baltimore,
Maryland, United States
In order to resolve the complex microstructures and
neural connectivity in the gray matter structures, high
spatial and angular resolution is critical but remains
challenging in vivo. We have achieved high-resolution
HARDI (0.1 mm isotropic, 60 directions) of live the
mouse brain using localized imaging technique and a 3D
fast imaging sequence. Several potential tracts within
the mouse hippocampus were reconstructed, and single
subject and group average tractography data showed the
tracts originated from the CA1 and dentate gyrus agreed
with existing tracer-based studies. The technique could
potentially be used to non-invasively examine the
neuronal pathways in gray matter structures.
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