Abstract #2673
Neurite Orientation Dispersion and Density Imaging (NODDI) Adds Biophysical Insight of White Matter Microstructural Injury in Neonatal Encephalopathy
Peter J Lally 1 , Hui Zhang 2 , Shreela S Pauliah 1 , David L Price 3 , Alan Bainbridge 3 , Ernest B Cady 3 , Seetha Shankaran 4 , and Sudhin Thayyil 1
1
Perinatal Neurology and Neonatology,
Imperial College London, London, United Kingdom,
2
Centre
for Medical Image Computing, University College London,
London, United Kingdom,
3
Medical
Physics and Biongineering, University College London
Hospitals NHS Trust, London, United Kingdom,
4
School
of Medicine, Wayne State University, Detroit, Michigan,
United States
Descriptors of white matter (WM) diffusivity correlate
with adverse neurological outcome in neonatal
encephalopathy (NE). WM integrity measures derived from
clinical diffusion tensor imaging are difficult to
interpret in terms of microstructural morphology. We
aimed to examine changes in WM microstructure associated
with NE, and relate these to tangible biophysical models
by fitting single-shell DTI data to the neurite
orientation dispersion and density imaging (NODDI)
model. Single subject maps of NODDI indices were noisy,
but cohort-averaged maps (n=31) enabled characteristic
changes in WM fractional anisotropy and radial
diffusivity to be related to a possible reduction in
neurite density.
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