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Abstract #2672

Structural Graph Analysis of Left and Right Temporal Lobe Epilepsy using Diffusion Spectrum Imaging

Alia Lemkaddem 1 , Alessandro Daducci 1 , Franois Lazeyras 2 , Margitta Seeck 3 , Jean-Philippe Thiran 1,4 , and Serge Vulliemoz 3

1 Signal Processing Laboratory (LTS5), Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Switzerland, 2 Dpt of Radiology, University Hospital of Geneva, Switzerland, 3 EEG and Epilepsy Unit, Neurology clinic, University Hospitals and Faculty of Medicine of Geneva, Switzerland, 4 Dpt of Radiology, University Hospital Center (CHUV) and University of Lausanne (UNIL), Switzerland

In this study we investigated the effect of right-sided and left-sided temporal lobe epilepsy (TLE) on the global characteristics of brain connectivity estimated by topological measures. We used DSI to construct a connectivity matrix where the nodes represents the anatomical ROIs and the edges are the connections between any pair of ROIs. A significant difference was found between the patient group vs control group in characteristic path length( RTLE: p=0.007, LTLE: p=0.000493), clustering coefficient (p=0.0079, p=0.00025), strength (p=0.0088, p=0.00081) and efficiency (p=0.0099, p=0.00042). This suggests that the TLEs the network is less efficient compared to the network of the control group.

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