Abstract #2672
Structural Graph Analysis of Left and Right Temporal Lobe Epilepsy using Diffusion Spectrum Imaging
Alia Lemkaddem 1 , Alessandro Daducci 1 , Franois Lazeyras 2 , Margitta Seeck 3 , Jean-Philippe Thiran 1,4 , and Serge Vulliemoz 3
1
Signal Processing Laboratory (LTS5), Ecole
Polytechnique Fdrale de Lausanne (EPFL), Lausanne,
Switzerland,
2
Dpt
of Radiology, University Hospital of Geneva,
Switzerland,
3
EEG and Epilepsy Unit, Neurology
clinic, University Hospitals and Faculty of Medicine of
Geneva, Switzerland,
4
Dpt
of Radiology, University Hospital Center (CHUV) and
University of Lausanne (UNIL), Switzerland
In this study we investigated the effect of right-sided
and left-sided temporal lobe epilepsy (TLE) on the
global characteristics of brain connectivity estimated
by topological measures. We used DSI to construct a
connectivity matrix where the nodes represents the
anatomical ROIs and the edges are the connections
between any pair of ROIs. A significant difference was
found between the patient group vs control group in
characteristic path length( RTLE: p=0.007, LTLE:
p=0.000493), clustering coefficient (p=0.0079,
p=0.00025), strength (p=0.0088, p=0.00081) and
efficiency (p=0.0099, p=0.00042). This suggests that the
TLEs the network is less efficient compared to the
network of the control group.
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