Abstract #2677
The effect of b-value on ADC values in a rat U87 brain tumor model
Alexander D Cohen 1 , Kimberly R Pechman 2 , Mona Al-Gizawiy 3 , Christopher R Chitamber 4 , and Kathleen M Schmainda 1,3
1
Biophysics, Medical College of Wisconsin,
Milwaukee, WI, United States,
2
Neurosurgery,
Medical College of Wisconsin, Milwaukee, WI, United
States,
3
Radiology,
Medical College of Wisconsin, Milwaukee, WI, United
States,
4
Medicine,
Medical College of Wisconsin, Milwaukee, WI, United
States
The apparent diffusion coefficient (ADC) depends on
which b-values are used in its calculation. In this
study, ADC is calculated using different combinations of
b-values and compared between tumor and gray matter (GM)
in a rat brain tumor model.
Higher
ADC
was found in tumor vs. GM when
lower
b-values
were used in its calculation, despite increased
cellularity in the tumor seen on histology.
Lower
ADC
was found in tumor vs. GM when
higher
b-values
were used in its calculation. ADC calculated with high
b-values may be more sensitive to cellularity as the
faster diffusing extracellular components have been
suppressed.
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