Abstract #2678
Assessing white matter microstructure in regions with different myelin architecture
Samuel Groeschel 1,2 , Thomas Schultz 3,4 , Gisela Hagberg 2,5 , Uwe Klose 6 , Till-Karsten Hauser 6 , Oliver Bieri 7 , Thomas Prasloski 8 , Alex MacKay 8 , Ingeborg Krgeloh-Mann 1 , and Klaus Scheffler 2,5
1
University Children's Hospital, Tuebingen,
Germany,
2
MPI
for Biological Cybernetics, Tuebingen, Germany,
3
Institute
of Computer Science, University of Bonn, Germany,
4
MPI
for Instelligent Systems, Tuebingen, Germany,
5
Biomedical
Magnetic Resonance, University Hospital, Tuebingen,
Germany,
6
Department
of Diagnostic and Interventional Neuroradiology,
University Hospital, Tuebingen, Germany,
7
Radiological
Physics, University of Basel, Switzerland,
8
University
of British Columbia, Vancouver, BC, Canada
In our study we assessed several white matter (WM)
imaging protocols in their ability to detect the known
differences in myelin architecture between the
cortico-spinal tract and frontal WM regions in 18
healthy adolescents. We found that diffusion-weighted
imaging parameters and myelin water fraction can give
quantitative and most sensitive information about
differences in myelin microstructure. From the diffusion
parameters, neurite density (NODDI) was found to be more
sensitive than fractional anisotropy (FA), underlining
the limitation of FA in WM crossing fibre regions.
Furthermore, these parameters successfully quantified
loss of myelin in 5 patients with Metachromatic
Leukodystrophy.
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