Abstract #2684
Diffusion basis spectrum imaging (DBSI) and manganese-enhanced MRI (MEMRI) detect axonal pathologies with decreased axonal transport in optic nerves of DBA/2J mice
Chia-Wen Chiang 1 , Tsen-Hsuan Lin 2 , Joong Hee Kim 1 , and Sheng-Kwei Song 1,3
1
Radiology, Washington University School of
Medicine, St. Louis, MO, United States,
2
Physics,
Washington University, St. Louis, MO, United States,
3
The
Hope Center for Neurological Disorders, Washington
University School of Medicine, St. Louis, MO, United
States
In this study, in vivo diffusion basis spectrum imaging
(DBSI) and manganese-enhanced MRI (MEMRI) were performed
to assess axonal pathologies (inflammation,
demyelination and axonal injury) and to determine the
degree of axonal transport deficit in 12-month old DBA/2J
mice, a rodent model of glaucoma which develops
progressive degeneration of visual function mimicking
human glaucoma. Our results suggest that DBA/2J mice
developed inflammation, axonal injury, demyelination
with significant axonal transport disruption in optic
nerves compared with the age-matched controls.
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