Diffusion MRI measurement of muscle fiber size and sarcolemma permeability in normal skeletal muscle growth

We quantified the microstructural changes in normal skeletal muscle growth using time-dependent DTI combined with random permeable barrier model (RPBM). A DTI study with multiple diffusion times was conducted with 4-5 weeks and 10-12 weeks old mice, followed by immunohistochemistry staining of collagen-IV and aquaporin-4. Overall, young mice had lower unrestricted diffusivity, higher membrane surface-to-volume (S/V) ratio, and lower membrane permeability than the old mice. Our preliminary results demonstrate that the DTI-RPBM measures can be used to monitor muscle growth in wild type mice, and substantiates the potential of using the DTI-RPBM measures as quantitative biomarkers of myopathy.

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