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Abstract #2702

Spin labeling MRI with Look-Locker readout for improved portal venous perfusion quantification

Marijn van Stralen 1 , Hanke Schalkx 2 , Nicky H.G.M. Peters 2 , Wouter Veldhuis 2 , Maarten S Van Leeuwen 2 , Maurice A.A.J. van den Bosch 2 , Josien P.W. Pluim 1 , and Esben T. Petersen 2

1 Image Sciences Institute, University Medical Center, Utrecht, Netherlands, 2 Radiology, University Medical Center, Utrecht, Netherlands

Spin labeling (SL) MRI of the liver has not yet been widely investigated. Previously used single time point readout does not take bolus arrival time differences into account, hampering quantification. Therefore, SL-MRI with Look-Locker (LL) readout was investigated with pulsed and pseudo-continuous labeling strategies in healthy volunteers. We found regional and intersubject differences in bolus arrival time. Hepatic SL-MRI with LL readout could successfully quantify portal venous perfusion, with both labeling strategies, and was comparable to flow-based perfusion.

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