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Abstract #2720

Changes in arterial arrival time (AAT) and cerebral blood flow (CBF) with hypercarbia and hypercarbic hyperoxia

Manus Joseph Donahue 1 , Carlos Faraco 1 , Lindsey Dethrage 1 , Swati Rane 1 , Megan Strother 1 , Jeroen Hendrikse 2 , and Jeroen Siero 2

1 Vanderbilt University, Nashville, TN, United States, 2 University Medical Center Utrecht, Utrecht, Netherlands

We perform multi-TI ASL measurements to simultaneously quantify CBF and AAT in multiple brain regions in response to different types of common gas stimuli: (i) room air, (ii) 5% CO2 / 95% room air (i.e., CO2/air), and (iii) 5% CO2 / 95% O2 (i.e., carbogen). Relative to room air, in all lobes, CBF was higher with CO2/air (P<0.05; range=14.9-24.5%) and carbogen (range=9.3-21.6%) stimulus, and AAT lower (P<0.05; CO2/air range=-13.4 - -20.6%; carbogen range=-9.2 - -12.1%). Values can be used as an exemplar for understanding how hypercarbia-induced CBF changes are influenced by blood water arrival time.

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