Abstract #2720
Changes in arterial arrival time (AAT) and cerebral blood flow (CBF) with hypercarbia and hypercarbic hyperoxia
Manus Joseph Donahue 1 , Carlos Faraco 1 , Lindsey Dethrage 1 , Swati Rane 1 , Megan Strother 1 , Jeroen Hendrikse 2 , and Jeroen Siero 2
1
Vanderbilt University, Nashville, TN, United
States,
2
University
Medical Center Utrecht, Utrecht, Netherlands
We perform multi-TI ASL measurements to simultaneously
quantify CBF and AAT in multiple brain regions in
response to different types of common gas stimuli: (i)
room air, (ii) 5% CO2 / 95% room air (i.e., CO2/air),
and (iii) 5% CO2 / 95% O2 (i.e., carbogen). Relative to
room air, in all lobes, CBF was higher with CO2/air
(P<0.05; range=14.9-24.5%) and carbogen
(range=9.3-21.6%) stimulus, and AAT lower (P<0.05;
CO2/air range=-13.4 - -20.6%; carbogen range=-9.2 -
-12.1%). Values can be used as an exemplar for
understanding how hypercarbia-induced CBF changes are
influenced by blood water arrival time.
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