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Abstract #2721

Combined use of arterial spin labeling and MRS to determine the severity of injury in neonates with hypoxic-ischaemic encephalopathy

Magdalena Sokolska 1,2 , Maia Proisy 3 , Cristina Uria-Avellanal 3 , Alan Bainbridge 2 , Ernest Cady 2 , David Thomas 1 , Nicola Robertson 3 , and Xavier Golay 1

1 UCL Institute of Neurology, London, London, United Kingdom, 2 UCH Medical Physics and Bioengineering, London, London, United Kingdom, 3 UCL Institute for Women's Health, London, United Kingdom

Cerebral blood flow (CBF) reflects cerebral metabolic demand, and can be altered in neonates with brain injury. Proton MR spectroscopy (MRS), in particular thalamic Lac/NAA peak ratio, has been shown to be the best predictor of clinical outcome so far1. Adding estimation of CBF to MR spectroscopy (MRS) has the potential to both increase understanding of the injury cause and progression and to help develop and assess new neuroprotective treatments. CBF can be quantified non-invasively using Arterial Spin Labeling (ASL). The aim of this study was to investigate neurophysiological changes in babies with suspected hypoxic ischaemic brain injury using MRS and ASL.

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