Abstract #2721
Combined use of arterial spin labeling and MRS to determine the severity of injury in neonates with hypoxic-ischaemic encephalopathy
Magdalena Sokolska 1,2 , Maia Proisy 3 , Cristina Uria-Avellanal 3 , Alan Bainbridge 2 , Ernest Cady 2 , David Thomas 1 , Nicola Robertson 3 , and Xavier Golay 1
1
UCL Institute of Neurology, London, London,
United Kingdom,
2
UCH
Medical Physics and Bioengineering, London, London,
United Kingdom,
3
UCL
Institute for Women's Health, London, United Kingdom
Cerebral blood flow (CBF) reflects cerebral metabolic
demand, and can be altered in neonates with brain
injury. Proton MR spectroscopy (MRS), in particular
thalamic Lac/NAA peak ratio, has been shown to be the
best predictor of clinical outcome so far1. Adding
estimation of CBF to MR spectroscopy (MRS) has the
potential to both increase understanding of the injury
cause and progression and to help develop and assess new
neuroprotective treatments. CBF can be quantified
non-invasively using Arterial Spin Labeling (ASL). The
aim of this study was to investigate neurophysiological
changes in babies with suspected hypoxic ischaemic brain
injury using MRS and ASL.
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