Abstract #2722
Accuracy and precision of pseudo-continuous arterial spin labeling perfusion during baseline and hypercapnia: a head-to-head comparison with 15 O H 2 O positron emission tomography
Dennis F R Heijtel 1 , Henri J M M Mutsaerts 1 , Esther Bakker 2 , Patrick Schober 3 , Markus F Stevens 4 , Esben T Petersen 5 , Bart N M van Berckel 2 , Charles B L M Majoie 1 , Jan Booij 6 , Matthias J P van Osch 7 , Ed T vanBavel 8 , Ronald Boellaard 2 , Adriaan A Lammertsma 2 , and Aart J Nederveen 1
1
Radiology, Academic Medical Center,
Amsterdam, Netherlands,
2
Radiology
and Nuclear Medicine, VU University Medical Center,
Amsterdam, Netherlands,
3
Anesthesiology,
VU University Medical Center, Amsterdam, Netherlands,
4
Anesthesiology,
Academic Medical Center, Amsterdam, Netherlands,
5
Radiology,
University Medical Center Utrecht, Utrecht, Netherlands,
6
Nuclear
Medicine, Academic Medical Center, Amsterdam,
Netherlands,
7
C.J.
Gorter Center for High Field MRI, Radiology, Leiden
University Medical Center, Leiden, Netherlands,
8
Biomedical
Engineering and Physics, Academic Medical Center,
Amsterdam, Netherlands
In this study we assessed the accuracy and precision of
quantitative pCASL-based CBF and CVR measurements by
performing a head-to-head comparison with
15
O
H
2
O PET, based on quantitative CBF
measurements during baseline and hypercapnia. We
demonstrate that pCASL CBF imaging is accurate during
both baseline and hypercapnia with a precision
comparable to
15
O
H
2
O PET.
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