Abstract #2747
Prostate cancer localization by magnetic resonance dispersion imaging
Massimo Mischi 1 , Simona Turco 1 , Cristina Lavini 2 , Marcel Breeuwer 3 , Jean de la Rosette 4 , Mark Engelbrecht 2 , and Hessel Wijkstra 1,4
1
Electrical Engineering, Eindhoven University
of Technology, Eindhoven, Netherlands,
2
Radiology,
Academic Medical Center University of Amsterdam,
Netherlands,
3
Philips
Healthcare, Netherlands,
4
Urology,
Academic Medical Center University of Amsterdam,
Netherlands
MR dispersion imaging (MRDI) is proposed as a new method
for characterization of the microvascular architecture
by assessment of contrast intravascular dispersion in
DCE MRI. Dispersion is estimated by fitting a new model
that integrates the Tofts model for extravascular
leakage together with a solution of the
convective-dispersion equation. Based on the established
link between angiogenesis and cancer growth, this method
is evaluated for localization of prostate cancer by
comparison with histology results following radical
prostatectomy. Without need for an arterial input
function, MRDI enables accurate localization of prostate
cancer, as confirmed by our initial validation with 90
MRI slices in 15 patients.
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