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Abstract #2748

Evaluation of Vascular Transfer Constants using Dynamic T1-Mapping during Contrast Agent Administration

Uwe Klose 1 , Sotirios Bisdas 1 , Herbert Kstler 2 , and Johannes Tran-Gia 2

1 Department of Diagnostic and Interventional Neuroradiology, University Hospital of Tbingen, Tbingen, Germany, 2 Institute of Radiology, University of Wrzburg, Wrzburg, Germany

A new fast T1 mapping method, based on the acquisition of 1000 single radial trajectories within a time of 6 s, allows the direct observation of T1 changes during DCE measurements. A single slice of a patient with a primary brain lymphoma was examined. In four regions, the dynamic T1 values were evaluated and Patlak plots were calculated, using the signal in the superior sagittal sinus to estimate the plasma concentration C p (t). K trans values could be estimated as slopes of fitted straight lines in the Patlak plot. Remarkably low residuals between data points and fitted lines were found.

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