Abstract #2749
Quantification of subtle blood-brain barrier permeability in white matter using DCE-MRI
Anna K Heye 1 , Michael J Thrippleton 1 , Maria del C Valds Hernndez 1 , Paul A Armitage 2 , and Joanna M Wardlaw 1
1
Brain Research Imaging Centre, Division of
Neuroimaging Sciences, University of Edinburgh,
Edinburgh, Scotland, United Kingdom,
2
Academic
Unit of Radiology, Department of Cardiovascular Science,
Medical School, University of Sheffield, Sheffield,
England, United Kingdom
This study uses T1-weighted DCE-MRI to quantify subtle
blood-brain barrier permeability in normal-appearing
white matter and white matter lesions of patients with
mild stroke. We calculated Patlaks pharmacokinetic
parameters and two model-free measurements, all of which
suggest that permeability is enhanced in white matter
lesions when compared to normal-appearing white matter.
Moreover, we investigated the relationship between
model-free and pharmacokinetic parameters, showing
moderate to strong correlations.
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