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Abstract #2749

Quantification of subtle blood-brain barrier permeability in white matter using DCE-MRI

Anna K Heye 1 , Michael J Thrippleton 1 , Maria del C Valds Hernndez 1 , Paul A Armitage 2 , and Joanna M Wardlaw 1

1 Brain Research Imaging Centre, Division of Neuroimaging Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom, 2 Academic Unit of Radiology, Department of Cardiovascular Science, Medical School, University of Sheffield, Sheffield, England, United Kingdom

This study uses T1-weighted DCE-MRI to quantify subtle blood-brain barrier permeability in normal-appearing white matter and white matter lesions of patients with mild stroke. We calculated Patlaks pharmacokinetic parameters and two model-free measurements, all of which suggest that permeability is enhanced in white matter lesions when compared to normal-appearing white matter. Moreover, we investigated the relationship between model-free and pharmacokinetic parameters, showing moderate to strong correlations.

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