Abstract #2750
Clinical implementation of the Linear Reference Region Model for Dynamic Contrast-Enhanced MRI
Adam Bernstein 1 , Phillip H Kuo 2 , Mark D. Pagel 3 , and Julio Cardenas-Rodriguez 3
1
Department of Biomedical Engineering,
University of Arizona, Tucson, AZ, United States,
2
Department
of Medical Imaging, University of Arizona, Tucson, AZ,
United States,
3
Department
of Biomedical Engineering and Arizona Cancer Center,
University of Arizona, Tucson, AZ, United States
In this work we analyzed retrospectively DCE MRI data of
17 patients. A comparison between the Linear Reference
Region Model (LRRM) and the standard non-linear
Reference Region Model (NLRRM) was performed. Clinical
DCE MRI can be processed 90-400 times faster with the
LRRM than with the NLRRM. The fitting RMSE was
systematically 6-7 times higher for the NLRRM compared
to the LRRM. Our results suggest that the LRRM is more
reliable than the NLRRM when DCE MRI data with low SNR
and temporal resolution is available.
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