DCE-MRI and T 2 * Measurement in Women with Heavy Menstrual Bleeding Treated with Dexamathasone
Lucy E Kershaw 1 , Gillian MacNaught 2 , Mayank Serge Madhra 3 , Hilary O Critchley 3 , and Scott IK Semple 2
Christie Medical Physics and Engineering,
The Christie NHS Foundation Trust, Manchester, Gtr
Manchester, United Kingdom,
University of Edinburgh, Edinburgh, United Kingdom,
Centre for Reproductive Health, University of Edinburgh,
Edinburgh, United Kingdom
The aim of this study was to develop a DCE-MRI and T2*
measurement protocol for monitoring dexamethasone
therapy in women with heavy menstrual bleeding. A high
spatial resolution protocol was developed that
differentiated between inner and outer myometrium.
Uptake curves could be markedly different in shape
between patients, but T2* and DCE-MRI parameters were
found to be similar to those described in previous work.
No significant differences were found pre and post
therapy but quantitative blood loss is not yet available
for correlation with the measured parameters.
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