High Resolution Imaging of pH in an Isolated Perfused Rat with Hyperpolarized Bicarbonate Produced via Chemical Reaction

Synopsis: Several medical conditions such as acute lung injury, cancer, ischemia, and inflammation result in alterations to the acid-base balance in tissue. Hyperpolarized bicarbonate has been able to determine the pH in-vivo. However the highest polarization of bicarbonate is achieved using cesium salts. This is not translatable to a clinical setting, as cesium ions are highly toxic. We generate hyperpolarized bicarbonate by decarboxylating the hyperpolarized pyruvate. This leads to a high polarization without the use of cesium, and allows for increased imaging resolution. We demonstrate imaging with 1.2mmx1.2mm in plane resolution, which could be increased to 0.5mmx0.5mm.

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