Abstract #2771

Kinetic modeling of Hyperpolarized 13C-Pyruvate with Arbitrary RF flip angles in cancer

Naeim Bahrami ¹ , Christine Leon ¹ , Cornelius Von Morze ¹ , Daniel B. Vigneron ¹ , and Peder E.Z. Larson ¹

¹ Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, United States

The primary purpose of this research was to model the kinetics of hyperpolarized (HP) pyruvate and urea to provide improved characterization of cancerous tissues when using arbitrary RF flip angles in dynamic MRSI. This modeling has the ability to detect metabolic conversion and perfusion. The conversion constant of metabolites will increase in tumor with respect to healthy tissues. In this study, we measured T1 values of metabolites including pyruvate, urea, alanine, and lactate in tumor and healthy tissues.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.