Abstract #2770
Hyperpolarized [2- 13 C]-D-fructose Uptake and Metabolism in Brain Tissue
Kamil Lorenc 1 , Eugen Kubala 2,3 , Concetta V. Gringeri 2,4 , Markus Durst 4,5 , Ulrich Koellisch 4,5 , Annette Frank 2 , Markus Schwaiger 2 , Steffen J. Glaser 3 , Rolf F. Schulte 4 , and Marion I. Menzel 4
1
Nalecz Institute of Biocybernetics and
Biomedical Engineering, PAS, Warsaw, Poland,
2
Klinikum
rechts der Isar, TU Mnchen, Munich, Germany,
3
Department
of Chemistry, TU Mnchen, Munich, Germany,
4
GE
Global Research, Munich, Germany,
5
Institute
of Medical Engineering, TU Mnchen, Munich, Germany
Recently, there is growing evidence that D-fructose
plays a role in neuroenergetics. Depending on tissue
D-fructose is metabolized through Fructose-1-phosphate,
or Fructose-6-phosphate metabolic pathway, however, in
brain Fructose-6-phosphate metabolic pathway is used
exclusively. The aim was to find out if hyperpolarized
[2-
13
C]-D-fructose is able to cross blood
brain barrier in sufficient amount enabling the
measurement using 13CMMR. We observed a very clear
signal in all of the measurements, meaning that
D-fructose was able to cross blood brain barrier in
sufficient amount. In future D-fructose is a good
candidate for functional imaging studies, and due to
non-toxicity it may be applied in human.
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