Abstract #2778
High-resolution 2D MRI of 1 H and 13 C hyperpolarized contrast agents at 0.0475 T
Aaron M. Coffey 1,2 , Roman V. Shchepin 2 , Danila A. Barskiy 3,4 , Kirill V. Kovtunov 3,4 , Igor V. Koptyug 3,4 , Kevin W. Waddell 2,5 , Ping He 6 , Kirsten A. Groome 6 , Quinn A. Best 6 , Fan Shi 6 , Boyd M. Goodson 6 , and Eduard Y. Chekmenev 1,2
1
Biomedical Engineering, Vanderbilt
University, Nashville, TN, United States,
2
Radiology,
Vanderbilt University Institute of Imaging Science,
Nashville, TN, United States,
3
International
Tomography Center, Novosibirsk, 630090, Russian
Federation,
4
Novosibirsk
State University, Novosibirsk, 630090, Russian
Federation,
5
Physics,
Vanderbilt University, Nashville, TN, United States,
6
Chemistry
and Biochemistry, Southern Illinois University,
Carbondale, IL, United States
Nuclear spin polarization
P
is
a key factor for MRI sensitivity, with various
hyperpolarization techniques permitting orders of
magnitude increases beyond that afforded by static
magnetic fields. Low-field, resonance frequency
optimized rf coils can allow imaging of such
polarization with greater sensitivity than at high
field. High-resolution 0.0475 T proton and
13
C
2D GRE imaging is demonstrated for pyridine and
13
C-succinate
hyperpolarized via SABRE and PHIP respectively in a 5.75
mT parahydrogen polarizer. Proton in-plane resolution
was 94 μm for P ~ 0.5%, and
13
C
in-plane resolution was 250 μm with P ~ 13%.
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