In vivo Hyperpolarized 13C Chemical Shift Imaging using Variable Flip Angle and Centric Phase Encoding of Stimulated Mouse Muscle

MR spectroscopic imaging of hyperpolarized 13C1-pyruvate is a promising technique for in vivo mapping of metabolic information. This method is based on dynamic nuclear polarization (DNP) and on a rapid dissolution process to produce a highly polarized metabolic contrast agent. After injection, 13C1-pyruvate and its metabolic products 13C1-lactate, 13C1-alanine and 13C1-bicarbonate can be mapped using a Chemical Shift Imaging (CSI) sequence. In this study, a Variable Flip Angle (VFA) Centric Phase Encoding (CPE) CSI sequence was implemented and applied on hyperpolarized 13C1-pyruvate for imaging the metabolism of mice skeletal muscles during functional stimulations mimicking exercise.

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