Metabolism of Hyperpolarized [1- 13 C]pyruvate to Plasma Glucose in the Rat Liver

In vivo hepatic metabolism of hyperpolarized [1-13C]pyruvate is not known to produce 13C-enriched blood glucose. Rats were either infused simultaneously with [3-13C]pyruvate and [U-13C]octanoate or saline before injection with hyperpolarized [1-13C]pyruvate Hyperpolarized [13C]bicarbonate was observed in several animals. Carbon-13 isotopomer analysis of purified blood glucose showed a large amount of 13C enrichment from pyruvate/octanoate infused animals. Saline infused animals showed a small amount of 13C-enrichment. Also evident were spin-spin 13C couplings was observed as being derived from two molecules of [1-13C]pyruvate forming one molecule of glucose. Integration of hyperpolarized and conventional 13C-NMR is a powerful method for monitoring liver metabolism.

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