Abstract #2786
Chemical Shift Enhanced Acquisition of in vivo Hyperpolarized 13C Metabolism in 9.4T
Seungwook Yang 1 , Joonsung Lee 2,3 , Eunhae Joe 1 , Hansol Lee 1 , Young-Suk Choi 4 , Ho-Taek Song 4 , and Dong-Hyun Kim 1
1
Department of Electrical and Electronic
Engineering, Yonsei University, Seoul, Korea,
2
Nano-Medical
National Core Research Center, Yonsei University, Seoul,
Korea,
3
SIRIC,
Yonsei, Seoul, Korea,
4
Department
of Radiology, College of Medicine, Yonsei University,
Seoul, Korea
A method for frequency-selective, high-resolution
acquisition of hyperpolarized substrate and its
downstream metabolites in vivo in 9.4T is presented. The
spatial displacement caused by the chemical shift is
utilized in the acquisition of metabolite-selective
images by modifying the slice-selection gradients
duration and polarity. By doing so, spectral bands of
neighboring resonances can be pushed outside the subject
while acquisition is done in a frequency-interleaved
manner. In this work, a simple implementation of this
concept into a conventional 3D CSI sequence is
presented, along with initial application results from
in vivo mouse kidney experiment in 9.4T.
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