A Survey On The Effect Of Antioxidant And Metabolism Modifiers On Lung Metabolism Using Hyperpolarized 13C NMR
Hoora Shaghaghi 1 , Stephen Kadlecek 1 , Mehrdad Pourfathi 1 , Sarmad Siddiqui 1 , Profka Harrilla 1 , and Rahim R. Rizi 1
Radiology, University of Pennsylvania,
Philadelphia, Pennsylvania, United States
In order to develop a more comprehensive understanding
of lung metabolism, we investigated the underlying
mechanism of pulmonary metabolic changes in the presence
of several notable compounds with a known effect on the
biochemical activity of perfused lungs. These compounds
included dichloroacetate, a PDK inhibitor; glutathione,
an antioxidant and a LDH inhibitor; ascorbate, an
antioxidant; dehydroascorbate, the oxidized form of
ascorbate; and alpha-lipoic acid, a metabolism modifier.
Among these compounds, ascorbate had the most
significant effect on PDH flux. In a comparison of the
effects, we concluded that the mechanism of ascorbate
effect is not due to its antioxidant properties.
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