Abstract #2788
Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopic Imaging of Metabolism in a Mouse Model of Breast Cancer
Roberta M Strigel 1 , Erin Adamson 2 , David J Niles 2 , Amy Rapaich Moser 3,4 , Jeremy W Gordon 2 , Elizabeth S Burnside 1,4 , and Sean B Fain 1,2
1
Radiology, University of Wisconsin, Madison,
WI, United States,
2
Medical
Physics, University of Wisconsin, Madison, WI, United
States,
3
Human
Oncology, University of Wisconsin, Madison, WI, United
States,
4
Carbone
Cancer Center, University of Wisconsin, Madison, WI,
United States
Hyperpolarized(HP) carbon-13(
13
C) MR
spectroscopic imaging was performed to detect the
metabolic features of tumorigenesis in a mouse model of
mammary malignancy. 11 mice with tumors were imaged on a
4.7T small animal MR system. Dynamic
13
C
imaging was performed after intravenous (IV) injection
of HP
13
C-pyruvate
followed by dynamic contrast enhanced (DCE) MRI using IV
gadodiamide. Lactate was identified as a metabolite of
HP
13
C-pyruvate
in 2/11 mice. Preliminary results demonstrate
inconsistency between contrast-enhanced perfusion and HP
13
C-lactate,
suggesting that HP
13
C
imaging may identify spatial heterogeneity in
metabolism, within and between tumors, which differs
from perfusion with DCE MRI.
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