Suppression of unwanted resonances in hyperpolarized MR studies with neat [1- 13 C]lactic acid

Similar to pyruvate, neat [ ¹³ C]lactic acid appears to be the best form of lactate for dissolution DNP. Unfortunately the neat acid is prone to form a lactide dimer which overlaps spectrally onto product alanine. We investigated the use of a spectrally selective pre-saturation pulse sequence to eliminate dimer signal prior to hyperpolarized metabolic experiments in vivo.

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