Abstract #2796
Bolus Tracking for Improved Metabolic Imaging of Hyperpolarised Compounds
Markus Durst 1,2 , Ulrich Koellisch 1,2 , Concetta Gringeri 3 , Martin A. Janich 2 , Giaime Rancan 2,3 , Annette Frank 3 , Florian Wiesinger 2 , Marion I. Menzel 2 , Axel Haase 1 , and Rolf F. Schulte 2
1
IMETUM, Technische Universitt Mnchen,
Garching, Germany,
2
GE
Global Research, Garching, Germany,
3
Klinikum
rechts der Isar, Technische Universitt Mnchen,
Mnchen, Germany
Dynamic nuclear polarisation has enabled real-time
metabolic imaging of pyruvate and its metabolites.
Conventional imaging sequences do not account for
intersubject variations in biological parameters such as
perfusion. A fully automatic realtime bolus tracking
sequence for hyperpolarised substrates is presented
which starts the imaging acquisition at a defined point
on the bolus curve. This reduces artefacts, allows for a
more efficient use of hyperpolarised magnetisation and
enables a more reliable and consistent quantification of
metabolic activity. Using a copolarised urea and
pyruvate injection, spectrally selective tracking on
urea allows obtaining localised bolus tracking
information without depleting the pyruvate signal.
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