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Abstract #2795

Solvent effects of hyperpolarization drugs using signal amplification by reversible exchange (SABRE)

Haifeng Zeng 1,2 , Jiadi Xu 1,2 , Joseph Gillen 1,2 , Michael T. McMahon 1,2 , Dmitri Artemov 2 , Jean-Max Tyburn 3 , Joost A.B. Lohman 4 , Ryan Mewis 5 , Kevin D. Atkinson 5 , Gary G.R. Green 5 , Simon B. Duckett 5 , and Peter C.M. van Zijl 1,2

1 Kirby Center, Kennedy Krieger Institute, Baltimore, MD, United States, 2 Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3 Bruker BioSpin GmbH, Silberstreifen, Rheinstetten, Germany, 4 Bruker UK Limited, Banner Lane, Coventry, United Kingdom, 5 Department of Chemistry, University of York, Heslington, York, United Kingdom

Hyperpolarization can provide improved sensitivity for NMR, recently enabling the real-time monitoring of metabolism in vivo. Among the parahydrogen polarization techniques, the signal amplification by reversible exchange (SABRE) approach does not require chemical modification of substrate to polarize. Traditionally, methanol-d4 was used as solvent, which is not suitable for injection into animals. We therefore investigated the possibility of SABRE polarization in more compatible solvents namely DMSO, ethanol and water. In this work, we polarized 3-amino-1,2,4-triazine, pyrazinamide and isoniazid. In methanol-d4, up to -1400 times enhancement was obtained, corresponding to 8% polarization. In water, up to -65 times enhancement was obtained.

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