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Abstract #2794

Multi Gradient and Spin-Echo Radial Acquisition for Hyperpolarized 13 C MRSI

Marc S Ramirez 1 , Jaehyuk Lee 1 , Yunyun Chen 2 , Christopher M Walker 1 , Stephen Y Lai 2 , and James A Bankson 1

1 Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States, 2 Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, TX, United States

Spin-echo sequences offer several advantages for hyperpolarized MRSI, yet are challenging due to potential signal loss from the combination of flowing spins and lengthy 180 refocusing pulses. In this work, we developed and evaluated a multi-echo radial MRSI sequence in which a gradient-echo is used to measure the vascular input function of HP [1- 13 C] pyruvate in the blood and a train of spin-echoes is used to enhance the signal-to-noise of tumor measurements. The initial feasibility of this sequence was evaluated in dynamic HP phantoms ex vivo and in a murine model of anaplastic thyroid cancer in vivo.

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