Multi Gradient and Spin-Echo Radial Acquisition for Hyperpolarized 13 C MRSI
Marc S Ramirez 1 , Jaehyuk Lee 1 , Yunyun Chen 2 , Christopher M Walker 1 , Stephen Y Lai 2 , and James A Bankson 1
Department of Imaging Physics, The
University of Texas M.D. Anderson Cancer Center,
Houston, TX, United States,
of Head and Neck Surgery, The University of Texas M.D.
Anderson Cancer Center, TX, United States
Spin-echo sequences offer several advantages for
hyperpolarized MRSI, yet are challenging due to
potential signal loss from the combination of flowing
spins and lengthy 180 refocusing pulses. In this work,
we developed and evaluated a multi-echo radial MRSI
sequence in which a gradient-echo is used to measure the
vascular input function of HP [1-
pyruvate in the blood and a train of spin-echoes is used
to enhance the signal-to-noise of tumor measurements.
The initial feasibility of this sequence was evaluated
in dynamic HP phantoms ex vivo and in a murine model of
anaplastic thyroid cancer in vivo.
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