Abstract #2798
Non-invasive measurement of cellular membrane pH gradient in brain tumors using hyperpolarized 13 C-bicarbonate MSRI and CEST imaging
Heeseung Lim 1 , Nevin McVicar 1 , Francisco M Martinez-Santiesteban 1 , Robert Bartha 1,2 , and Timothy J Scholl 1,2
1
Medical Biophysics, Western University,
London, Ontario, Canada,
2
Robarts
Research Institute, Western University, London, Ontario,
Canada
The pH gradient between intracellular and extracellular
space changes in tumor. Tumors have a more alkaline pHi
and a more acidic pHe. In the current study, pHi and pHe
spatial distribution maps are measured in a glioma brain
tumor rat model using CEST
1
H-MRI
and hyperpolarized
13
C-MRS
respectively. Measured pHi and pHe in normal and tumor
tissue are consistent with previous work. The pH maps
demonstrate an increased transmembrane pH gradient, ∆pH
≈ 0.14 in the glioma compared to contralateral brain
tissue, ∆pH ≈ -0.34. This work represents to the
authors best knowledge the first in vivo quantitative
pH-gradient mapping.
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