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Abstract #2799

SNR comparison between CSI and spectral-spatial EPI acquisitions for hyperpolarized 13C metabolic imaging

Albert P Chen 1 and Charles H Cunningham 2,3

1 GE Healthcare, Toronto, ON, Canada, 2 Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 3 Deptartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada

In the first in human hyperpolarized 13C metabolic imaging study in prostate cancer patients, spectroscopic based chemical shift imaging technique was utilized to acquire spatially localized hyperpolarized [1-13C] pyruvate and [1-13C]lactate images from a single imaging window. Imaging based approaches utilizing selective excitation of a specific metabolite has been developed in recent years to enable acquisition of temporally resolved 13C metabolic imaging data throughout the time course of substrate infusion and its metabolic conversions. In this study, a comparison between a spectral-spatial EPI sequence designed for dynamic hyperpolarized 13C metabolic imaging and the standard CSI technique was performed in vivo.

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