Abstract #2811
Tracking cell transplants in vivo using a dual modality MRI/bioluminescence tomography platform
Moussa Chehade 1,2 , Amit K. Srivastava 2,3 , and Jeff W. M. Bulte 2,3
1
Department of Biomedical Engineering, The
Johns Hopkins University, Baltimore, MD, United States,
2
Cellular
Imaging Section, Institute for Cell Engineering, The
Johns Hopkins University School of Medicine, Baltimore,
MD, United States,
3
Department
of Radiology and Radiological Science, The Johns Hopkins
University School of Medicine, Baltimore, MD, United
States
Among the current challenges in cell transplantation
research is the need to monitor cell targeting and
survival in pre-clinical models using
in
vivo
imaging.
To improve upon current techniques, we developed a
method to co-register BLI and MR images of transplanted
cells using a specialized animal holder and an
a
priori
spatial
transformation paradigm.
In
vivo
testing
using ES cell transplants in mice showed that this
multimodal approach can visualize cell location with
higher accuracy and resolution while providing a more
sensitive measure of cell survival than could be
obtained with a single imaging modality.
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