Abstract #2821
The effect of loading nascent HDL with gadolinium phospholipids in the structural stability of the particles
Pedro Ramos-Cabrer 1,2 , Francois Fay 1 , Brenda L. Snchez-Gaytan 1 , Teresa Arias 3,4 , Jun Tang 1 , Jos Castillo 2 , Valentn Fuster 3,4 , Zahi A Fayad 1 , and Willem J. M. Mulder 1
1
Translational and Molecular Imaging
Institute (TMII), Icahn School of Medicine at Mount
Sinai, New York, NY, United States,
2
Department
of Neurology, Clinical Neurosciences Research
Laboratory, University Clinical Hospital of Santiago,
Health Sciences Institute of Santiago (IDIS), Santiago
de Compostela, Spain,
3
Department
of Cardiology, Zena and Michael A. Weiner Cardiovascular
Institute, Icahn School of Medicine at Mount Sinai, New
York, NY, United States,
4
Centro
Nacional de Investigaciones Cardiovasculares (CNIC),
Madrid, Spain
Labeling of bio-mimicking molecules such as HDL
lipoprotein with imaging probes is a very interesting
feature of molecular imaging techniques. However,
self-aggregating systems are formed under delicate
balances of non-covalent molecular interactions that are
modified by the introduction of imaging probes. Here we
describe how, over certain thresholds, the introduction
of high amounts of a gadolinium loaded lipids in nascent
HDL nanoparticles do not further increase the magnetic
relaxivities of HDL (as desired), but lead in turn to
the formation of large aggregates, that no longer can be
defined as HDL, and that will potentially present
different in vivo properties.
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