Abstract #2820
COMPUTATIONAL MODEL OF RESTRICTED DIFFUSION FOR NMR STUDIES OF SICKLE CELL DISEASE
Michael Oluwaseun Dada 1 , Bamidele Omotayo Awojoyogbe 1 , Simona Baroni 2 , and Samarendra Mohanty 3
1
Department of Physics, Federal University of
Technology, Minna, Niger State, Nigeria,
2
Invento
Laboratory, Molecular Biotechnology Center (MBC),
Torino, Turin, Italy,
3
Department of Physics,
Biophysics and Physiology group, University of Texas,
Arlington, Texas, United States
Sickle cell disease (SCD) is an inherited disorder of
hemoglobin structure that has no established cure in
adult patients. The most important pathophysiologic
event in sickle cell anemia, which explains most of its
clinical manifestations, is vascular occlusion; this may
involve both the micro- and macrovasculature1. The
primary process that leads to vascular occlusion is the
polymerization of sickle hemoglobin (Hb) on
deoxygenation, which in turn results in distortion of
the shape of red blood cells (RBC), cellular
dehydration, and decreased deformability and stickiness
of RBC, which promotes their adhesion to and activation
of the vascular endothelium1. SCD has been regarded as a
molecular disease without any established cure. Finding
a realiable cure for this disease may be dependent on
much we know about the molecular processes that lead to
it and how we could possibly represent them in terms of
images for classical observation. This study presents a
contribution to the understanding of SCD using the Bloch
Torrey equation so that we can easily represent the
associated chemical processes in MRI images. Vascular
occlusion is used to describe any form of blockage to
blood vessels.
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