Abstract #2819
EXCI-CEST: exploiting pharmaceutical excipients as safe MRI-CEST contrast agents
Dario Livio Longo 1,2 , Fatima Zzahra Moustaghfir 3 , Lorena Consolino 1,2 , Giuseppe Digilio 4 , and Silvio Aime 1,2
1
University of Turin, Torino, Italy,
2
Molecular
Imaging Center, University of Turin, Torino, Italy,
3
University
of Vrije Brussels, Brussels, Belgium,
4
Environmental
and Life Science, University of Eastern Piedmont "Amedeo
Avogadro", Alessandria, Italy
Molecules possessing exchangeable proton pools may be
selectively imaged within the MRI-CEST modality. Due to
the inherent low sensitivity of this technique, high
dosages are required to provide enough contrast, thus
limiting possible in vivo application to molecules with
high LD50 levels. In this study we explored the CEST
properties of several pharmaceutical excipients, due to
their high safety profiles. We found that most of them
were able to generate sufficient CEST saturation
transfer contrast for in vivo applications. Intravenous
injection into two different tumor bearing mice (breast
and melanoma tumor models) showed that it was possible
to monitor their uptake by CEST imaging.
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