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Abstract #2818

Monitoring the Accumulation of Natural Fruit-derived diaCEST Liposomes in B16 Melanoma

Xiaolei Song 1,2 , Tao Yu 1,3 , Deepak Kadayakkara 1 , Kannie W Y Chan 1,2 , Yuan Qiao 4 , Jeff W M Bulte 1,2 , Peter CM van Zijl 1,2 , Justin S Hanes 3 , and Michael T McMahon 1,2

1 Division of MR Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, Maryland, United States, 2 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States, 3 Center for Nanomedicine, The Johns Hopkins University, Baltimore, Maryland, United States, 4 The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at Johns Hopkins Medical Institute, Maryland, United States

Nanocarriers designed for imaging are becoming a powerful tool in oncology, allowing not only tumor detection but also assessment of tumor blood vessel permeability. Liposomes loaded with non-metallic diaCEST MR agents enable evaluation of the efficacy of tumor targeting. Recently a new family of CEST agents was reported, i.e., salicylic acid (SA) and analogues, which contain labile protons with large resonance shifts from water. We developed a series of SA-analogue liposomes for CEST MRI. Of these, 2,4-Dihydroxybenzoic acid, a fruit metabolite, showed the best liposomal retention (>40%) in vitro and also in vivo in mice bearing B16 melanomas, namely 3% CEST contrast.

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