Odorant stimulation manganese enhanced MRI for olfactory pathway after intranasal manganese administration
Byungmok Kim 1 , Mun Han 1 , Yongmin Chang 1,2 , and Hui Joong Lee* 3
Department of Medical & Biological
Engineering, Kyungpook National University, Daegu,
of Radiology & Molecular Medicine, School of Medicine,
Kyungpook National University, Daegu, Korea,
of Radiology, Kyungpook National University, Daegu,
The aim of this study is to investigate the central
nervous system (CNS) delivery of manganese following
intranasal administration form the nasal passage to the
CNS, response to different olfactory stimulants.
Olfactory bulb in the signal intensity increased about
Formic acid and Linalool. Acetone, Normal saline reduced
the signal intensity, but there was statistically
difference about four stimuli. Change of signal
intensity on cerebral cortex, amygdale, pons and
cerebellum showed statistical differences according to
four stimuli (P<0.05). In conclusion, manganese-enhanced
MRI revealed different manganese uptake on olfactory
pathway according to different olfactory stimuli, which
suggest activity-induced manganese-dependent MRI of
olfactory pathway dependant on olfactory function.
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