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Abstract #2827

MEMRI of diabetic retinas during light and dark adaptation at 11.7T

Bryan H De La Garza 1 , Chakradhar Velagapudi 2 , Hanna E Abboud 2 , Guang Li 1 , and Timothy Q Duong 1

1 Research Imaging Institute, Department of Radiology/Ophthalmology, Univ. Of Texas Health Science Center, San Antonio, Tx, United States, 2 Dept of Medicine-Renal Diseases, Univ of Texas Health Science Center, San Antonio, Tx, United States

Manganese-enhanced MRI (MEMRI) was used to investigate the calcium activity in different layers of the retina of diabetic retinopathy (DR) rats under light and dark adaptation 14 and 30 days after streptozocin injection. In normals, dark adaption lowered inner retina MEMRI activity, increased outer retina activity, but did not affect the choroid when compared to light adaptation. In DR rats compared to controls, MEMRI revealed reduced Mn uptake in the inner, outer, and choroid layers. Differential reduced MEMRI activity in dark was observed in the outer layer in DR rats compared to controls, suggesting outer retina dysfunction at early DR

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