Abstract #2830
Manganese-enhanced MRI combined with acoustic startle reflex testing would be useful as an imaging biomarker for tinnitus
Mun Han 1 , Da Jung Jung 2 , Kyu Yup Lee 2 , Yongmin Chang* 1,3 , and Hui Joong Lee* 4
1
Department of Medical & Biological
Engineering, Kyungpook National University, Daegu,
Korea,
2
Department
of Otorhinolaryngology & Head and Neck surgery,
Kyungpook National University, Daegu, Korea,
3
Department
of Radiology & Molecular Medicine, Kyungpook National
University, Daegu, Korea,
4
Department
of Radiology, Kyungpook National University, Daegu,
Korea
Animal models continue to improve our understanding of
tinnitus pathogenesis and aid in development of new
diagnosis. However, there are no diagnostic biomarkers
for tinnitus-related pathophysiology for use in animal.
To address this disparity, two complementary methods
were combined to examine reliable tinnitus models:
manganese-enhanced MRI (MEMRI) and inhibition of the
acoustic startle reflex (ASR) test. Salicylate-induced
tinnitus resulted in many manganese uptake compared to
normal model. Relative to that in controls, high signal
intensity is shown in the areas of the cochlea and
cochlear nucleus in salicylate group, displaying clear
difference in six hour and twelve hour MEMRI image. Our
results provide the foundation for future studies
correlating the longevity of tinnitus with neuronal
activity in the cochlea and specific brain regions.
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