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Abstract #2831

Motor and Cognitive Processing Networks show increased Manganese Accumulation in Metal Workers

Chien-Lin Yeh 1,2 , Elizabeth Zauber 3 , Sandy Snyder 1 , Zaiyang Long 1,2 , and Ulrike Dydak 1,2

1 School of Health Sciences, Purdue University, West lafayette, Indiana, United States, 2 Dept. of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States, 3 Dept. of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, United States

While the paramagnetic properties of Mangnaese (Mn) are highly used as contrast agent for MRI, little is known about the spatial distribution of Mn accumulation in human cortical brain areas due to occupational Mn exposure. This study uses 3D T1 mapping to analyze whole brain Mn deposition in a group of welders. Findings of significant Mn accumulation in motor regulation and visuospatial networks are consistent with neuropsychological studies on the neurotoxic effects of Mn exposure, suggesting that the location of Mn accumulation affects the function of the corresponding brain networks.

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