Abstract #2831
Motor and Cognitive Processing Networks show increased Manganese Accumulation in Metal Workers
Chien-Lin Yeh 1,2 , Elizabeth Zauber 3 , Sandy Snyder 1 , Zaiyang Long 1,2 , and Ulrike Dydak 1,2
1
School of Health Sciences, Purdue
University, West lafayette, Indiana, United States,
2
Dept.
of Radiology and Imaging Sciences, Indiana University
School of Medicine, Indianapolis, Indiana, United
States,
3
Dept.
of Neurology, Indiana University School of Medicine,
Indianapolis, Indiana, United States
While the paramagnetic properties of Mangnaese (Mn) are
highly used as contrast agent for MRI, little is known
about the spatial distribution of Mn accumulation in
human cortical brain areas due to occupational Mn
exposure. This study uses 3D T1 mapping to analyze whole
brain Mn deposition in a group of welders. Findings of
significant Mn accumulation in motor regulation and
visuospatial networks are consistent with
neuropsychological studies on the neurotoxic effects of
Mn exposure, suggesting that the location of Mn
accumulation affects the function of the corresponding
brain networks.
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