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Abstract #2832

MEMRI Reflects Human Neuropathology in a Murine Model of neuroAIDS

Aditya N Bade 1 , Santhi Gorantla 1 , Prasanta Dash 1 , Edward Makarov 1 , Larisa Y Poluektova 1 , Howard E Gendelman 1 , Michael D Boska 1,2 , and Yutong Liu 1,2

1 Pharmacology and Experimental neuroscience, University of Nebraska Medical Center, Omaha, NE, United States, 2 Department of Radiology, University of Nebraska Medical Center, Omaha, Omaha, NE, United States

Progressive HIV infection commonly leads to cognitive impairments. Disease complexity for what is commonly called HIV-associated neurocognitive disorders (HAND) is reflected by co-morbid conditions including substance abuse, psychiatric disease, aging, society and environment factors. To date, no reliable diagnostic tests for disease are available. In this study, we used MEMRI to evaluate changes in the brains of humanized mice due directly to HIV-1 infection. We analyzed data in individual neurostructures using a MEMRI-based brain atlas. We showed that decrease in signal enhancement suggests neuronal impairments in brain regions of infected mice, and corresponds to viral load and immune cell losses.

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