Abstract #2832
MEMRI Reflects Human Neuropathology in a Murine Model of neuroAIDS
Aditya N Bade 1 , Santhi Gorantla 1 , Prasanta Dash 1 , Edward Makarov 1 , Larisa Y Poluektova 1 , Howard E Gendelman 1 , Michael D Boska 1,2 , and Yutong Liu 1,2
1
Pharmacology and Experimental neuroscience,
University of Nebraska Medical Center, Omaha, NE, United
States,
2
Department
of Radiology, University of Nebraska Medical Center,
Omaha, Omaha, NE, United States
Progressive HIV infection commonly leads to cognitive
impairments. Disease complexity for what is commonly
called HIV-associated neurocognitive disorders (HAND) is
reflected by co-morbid conditions including substance
abuse, psychiatric disease, aging, society and
environment factors. To date, no reliable diagnostic
tests for disease are available. In this study, we used
MEMRI to evaluate changes in the brains of humanized
mice due directly to HIV-1 infection. We analyzed data
in individual neurostructures using a MEMRI-based brain
atlas. We showed that decrease in signal enhancement
suggests neuronal impairments in brain regions of
infected mice, and corresponds to viral load and immune
cell losses.
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