Abstract #2834
Variations in intra- and extracellular water component differentiation using intrathecal and subcutaneous injections of manganese chloride
Mohammed Salman Shazeeb 1,2
1
Radiology, University of Massachusetts
Medical School, Worcester, MA, United States,
2
Biomedical
Engineering, Worcester Polytechnic Institute, Worcester,
MA, United States
Diffusion-weighted NMR techniques have established that
the ADC of cerebral tissue water decreases during
ischemia. However, it remains unclear whether the ADC
change occurs due to changes in the intracellular (IC)
space, extracellular (EC) space, or both. Past works
have measured compartment-specific diffusion
coefficients using gadolinium as an EC MR contrast agent
which reduces the longitudinal (T1) relaxation time of
the EC space. In this study, we investigate an
alternative approach by using manganese (Mn2+), which
acts as a calcium analogue. Mn2+ uptake by cells causes
T1 of IC water to shorten, thus allowing differentiation
between the compartmental MR signals.
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